Efficacy and Safety of lprostadil in Patients with Peripheral Arterial Occlusive Disease Fontaine Stage IV: Results of a Placebo Controlled Randomised Multicentre Trial (ESPECIAL)
Dr. H. Lawall, A.Pokrovsky, et. al.
Peripheral arterial occlusive disease (PAOD) Fontaine Stage IV, the most serious form of critical limb ischemia (CLI), ist the clinical endpoint of PAOD. Despite its subacute or chronic appearance immediate action is necessary since tissue perfusion is markedly reduced and there is the threat of major amputation within 1 year.